Our lab engineers three-dimensional, polymer-based scaffolds to mimic the natural extracellular matrix by providing biological, chemical, and mechanical cues to cells. These scaffolds are designed for tissue repair in various organ systems. Scaffold systems used include hydrogels and interpenetrating polymer networks.
Drug discovery and development is hampered by high failure rates attributed to the reliance on non-human animal models employed during safety and efficacy testing. Here, we try to establish in vitro models of human cardiac and liver tissue. We propose to use a combination of integrated microfluidic systems with electrical and optical detection capability, dynamic controls, and advanced biomaterials to regulate structural organization function of cardiomyocytes and hepatocytes.