Publications -
 

Publications

Recent Papers

2020

  • Spaulding, Kimberly A., et al. “Myocardial injection of a thermoresponsive hydrogel with reactive oxygen species scavenger properties improves border zone contractility.” Journal of Biomedical Materials Research Part A (2020).
  • Wang, Chenyan, et al. “Maladaptive Contractility of 3D Human Cardiac Microtissues to Mechanical Nonuniformity.” Advanced Healthcare Materials 9.8 (2020): 1901373.
  • Jæger, Karoline Horgmo, et al. “Improved computational identification of drug response using optical measurements of human stem cell derived cardiomyocytes in microphysiological systems.” Frontiers in pharmacology 10 (2020): 1648.

2019

  • Browne, Shane, Samir Hossainy, and Kevin Healy. “Hyaluronic Acid Macromer Molecular Weight Dictates the Biophysical Properties and in Vitro Cellular Response to Semisynthetic Hydrogels.” ACS Biomaterials Science & Engineering 6.2 (2019): 1135-1143.
  • Matsumura, Yasumoto, et al. “Intramyocardial injection of a fully synthetic hydrogel attenuates left ventricular remodeling post myocardial infarction.” Biomaterials (2019): 119289
  • Browne, Shane, and Kevin E. Healy. “Matrix-assisted cell transplantation for tissue vascularization.” Advanced drug delivery reviews (2019).
  • Boggess, Steven C., et al. “New Molecular Scaffolds for Fluorescent Voltage Indicators.” ACS chemical biology 14.3 (2019): 390-396.
  • Natividad-Diaz, Sylvia L., et al. “A combined hiPSC-derived endothelial cell and in vitro microfluidic platform for assessing biomaterial-based angiogenesis.” Biomaterials 194 (2019): 73-83.

2018

  • Tveito, Aslak, et al. “Inversion and computational maturation of drug response using human stem cell derived cardiomyocytes in microphysiological systems.” Scientific reports 8.1 (2018): 17626.
  • Ma, Z. et al. Contractile deficits in engineered cardiac microtissues as a result of MYBPC3 deficiency and mechanical overload. Nature Biomedical Engineering (2018). doi:10.1038/s41551-018-0280-4
  • Hoang, P. et al. Quantitatively Characterizing Drug-Induced Arrhythmic Contractile Motions of Human Stem Cell-Derived Cardiomyocytes. Biotechnology and Bioengineering (2018). doi:10.1002/bit.26609
  •  Giannobile, W. et al. Dental, Oral, and Craniofacial Regenerative Medicine: Transforming Biotechnologies for Innovating Patient Care. Journal of Dental Research 97, 361–363 (2018).
  •  Browne, S. et al. TGF-β1/CD105 signaling controls vascular network formation within growth factor sequestering hyaluronic acid hydrogels. Plos One 13, (2018).
  • Tharp K. et al. Actomyosin-mediated tension orchestrates uncoupled respiration in adipose tissues. Cell Metabolism 27 (3), 602-615 (2018).
  • Silva, L. P. D. et al. Gellan Gum Hydrogels with Enzyme-Sensitive Biodegradation and Endothelial Cell Biorecognition Sites. Advanced Healthcare Materials 7, 1700686 (2018).
  • Zbinden, A. et al. Multivalent conjugates of basic fibroblast growth factor enhance in vitro proliferation and migration of endothelial cells. Biomaterials Science 6, 1076–1083 (2018).

2017

  • Povsic, T. J. et al. Navigating the Future of Cardiovascular Drug Development—Leveraging Novel Approaches to Drive Innovation and Drug Discovery: Summary of Findings from the Novel Cardiovascular Therapeutics Conference. Cardiovascular Drugs and Therapy 31, 445–458 (2017).
  • Garcia, M. B., Jha, A. K., Healy, K. E. & Wildsoet, C. F. A Bioengineering Approach to Myopia Control Tested in a Guinea Pig Model. Investigative Opthalmology & Visual Science 58, 1875 (2017).
  • Barros, A. et al. 7.41 Ureteral Stents Technology: Biodegradable and Drug-Eluting Perspective. Comprehensive Biomaterials II 793–812 (2017). doi:10.1016/b978-0-12-803581-8.10189
  • Maclean, F. L. et al. Galactose-functionalised PCL nanofibre scaffolds to attenuate inflammatory action of astrocytes in vitro and in vivo. Journal of Materials Chemistry B 5, 4073–4083 (2017)
  • Loskill, P. et al. WAT-on-a-chip: a physiologically relevant microfluidic system incorporating white adipose tissue. Lab on a Chip 17, 1645–1654 (2017).

2016

  • Barros, A. et al. Drug-eluting biodegradable ureteral stent: new approach for urothelial tumors of upper urinary tract cancer. International Journal of Pharmaceutics 513 (1-2), 227-237.
  • Svedlund, F., Altiok, E. & Healy, K. Branching Analysis of Multivalent Conjugates Using Size Exclusion Chromatography–Multiangle Light Scattering. Biomacromolecules 17, 3162-3171 (2016).
  • Altiok, E. I. et al. Multivalent hyaluronic acid bioconjugates improve sFlt-1 activity in vitro. Biomaterials93, 95–105 (2016).
  • Altiok, E. I. et al. sFlt Multivalent Conjugates Inhibit Angiogenesis and Improve Half-Life In Vivo. Plos One 11, (2016).
  • Jha, A. K. et al.Matrix metalloproteinase-13 mediated degradation of hyaluronic acid-based matrices orchestrates stem cell engraftment through vascular integration. Biomaterials89,136–147 (2016).
  • Huebsch, N. et al. Miniaturized iPS-Cell-Derived Cardiac Muscles for Physiologically Relevant Drug Response Analyses. Scientific Reports 6,(2016).
  • Ota, H. et al. 3D Printing: Application of 3D Printing for Smart Objects with Embedded Electronic Sensors and Systems (Adv. Mater. Technol. 1/2016). Advanced Materials Technologies 1, (2016).
  • Barros, A. et al. Mp23-07 Biodegradable Drug-Eluting Stents: Targeting Urothelial Tumors Of Upper Urinary Tract. The Journal of Urology 195,(2016).
  • Ota, H. et al. 3D Printing: Application of 3D Printing for Smart Objects with Embedded Electronic Sensors and Systems (Adv. Mater. Technol. 1/2016). Advanced Materials Technologies 1, (2016).
  • Almubarak, Sarah, et al. “Tissue engineering strategies for promoting vascularized bone regeneration.” Bone 83 (2016): 197-209.
  • Mathur, A., Ma, Z., Loskill, P., Jeeawoody, S. & Healy, K. E. In vitro cardiac tissue models: Current status and future prospects. Advanced Drug Delivery Reviews 96, 203–213 (2016).
  • Rodda, A. E. et al. Controlling integrin-based adhesion to a degradable electrospun fibre scaffold via SI-ATRP. Journal of Materials Chemistry B 4,7314–7322 (2016).
  • Loskill, P. et al. Organs-on-a-chip – Microphysiological platforms as in vitro models of cardiac and adipose tissue. Toxicology Letters 258, (2016).
  • Barros, A. et al. Upper urinary tract urothelial tumours targeted with biodegradable drug-eluting stents. European Urology Supplements 15, 180–181 (2016).

2015

  • Loskill, Peter, Sivan G. Marcus, Anurag Mathur, Willie Mae Reese, and Kevin E. Healy. “μOrgano: A Lego®-Like Plug & Play System for Modular Multi-Organ-Chips.” PLoS ONE 10, no. 10 (October 6, 2015): e0139587. doi:10.1371/journal.pone.0139587.
  • Mathur, Anurag, Zhen Ma, Peter Loskill, Shaheen Jeeawoody, and Kevin E. Healy. “In Vitro Cardiac Tissue Models: Current Status and Future Prospects.” Advanced Drug Delivery Reviews, September 30, 2015. doi:10.1016/j.addr.2015.09.011.
  • Han, Bruce W., Hans Layman, Nikhil A. Rode, Anthony Conway, David V. Schaffer, Nancy J. Boudreau, Wesley M. Jackson, and Kevin E. Healy. “Multivalent Conjugates of Sonic Hedgehog Accelerate Diabetic Wound Healing.” Tissue Engineering. Part A 21, no. 17–18 (September 2015): 2366–78. doi:10.1089/ten.TEA.2014.0281.
  • Jeon, Hojeong, Sangmo Koo, Willie Mae Reese, Peter Loskill, Costas P. Grigoropoulos, and Kevin E. Healy. “Directing Cell Migration and Organization via Nanocrater-Patterned Cell-Repellent Interfaces.” Nature Materials 14, no. 9 (September 2015): 918–23. doi:10.1038/nmat4342.
  • Tharp, Kevin M., Amit K. Jha, Judith Kraiczy, Alexandra Yesian, Grigory Karateev, Riccardo Sinisi, Elena A. Dubikovskaya, Kevin E. Healy, and Andreas Stahl. “Matrix Assisted Transplantation of Functional Beige Adipose Tissue.” Diabetes, August 20, 2015. doi:10.2337/db15-0728.
  • Ma, Zhen, Jason Wang, Peter Loskill, Nathaniel Huebsch, Sangmo Koo, Felicia L. Svedlund, Natalie C. Marks, et al. “Self-Organizing Human Cardiac Microchambers Mediated by Geometric Confinement.” Nature Communications 6 (July 14, 2015). doi:10.1038/ncomms8413.
  • Amit K. Jha, Anurag Mathur, Felicia L. Svedlund, Jianqin Ye, Yerem Yeghiazarians, Kevin E. Healy. Molecular weight and concentration of heparin in hyaluronic acid-based matrices modulates growth factor retention kinetics and stem cell fate. Journal of Controlled Release 209 (2015): 308-316.
  • Mathur, Anurag, Peter Loskill, Kaifeng Shao, Nathaniel Huebsch, SoonGweon Hong, Sivan G. Marcus, Natalie Marks et al. “Human iPSC-based Cardiac Microphysiological System For Drug Screening Applications.” Scientific reports 5 (2015).
  • Jha, Amit K., et al. “Enhanced survival and engraftment of transplanted stem cells using growth factor sequestering hydrogels.” Biomaterials 47 (2015): 1-12.
  • Huebsch, Nathaniel, Peter Loskill, Mohammad A. Mandegar, Natalie C. Marks, Alice S. Sheehan, Zhen Ma, Anurag A. Mathur et al. “Automated video-based analysis of contractility and calcium flux in human iPS–derived cardiomyocytes cultured over different spatial scales.” Tissue Engineering ja (2015).
  • Prestwich, Glenn D., and Kevin E. Healy. “Why regenerative medicine needs an extracellular matrix.” Expert opinion on biological therapy 15.1 (2015): 3-7.

2014

  • Spencer, C. Ian, Shiro Baba, Kenta Nakamura, Ethan A. Hua, Marie AF Sears, Chi-cheng Fu, Jianhua Zhang et al. “Calcium Transients Closely Reflect Prolonged Action Potentials in iPSC Models of Inherited Cardiac Arrhythmia.” Stem cell reports 3, no. 2 (2014): 269-281.
  • Jha, A. K., Jackson, W. M. & Healy, K. E. Controlling osteogenic stem cell differentiation via soft bioinspired hydrogels. PLoS One 9, e98640 (2014).
  • Vazin,T. et al. The effect of multivalent Sonic hedgehog on differentiation of human embryonic stem cells into dopaminergic and GABAergic neurons. Biomaterials 35,941–8 (2014).
  • Yum, K., Hong, S. G., Healy, K. E. & Lee, L. P. Physiologically relevant organs on chips. Biotechnol. J. 9, 16–27 (2014).
  • Ma, Z. et al. Three-dimensional filamentous human diseased cardiac tissue model. Biomaterials 35, 1367–77 (2014).

2013

  • Conway, A. et al. Multivalent ligands control stem cell behavior in vitro and in vivo. Nat. Nanotechnol. 8, 831–8 (2013).
  • Mathur, Anurag, Peter Loskill, Soongweon Hong, Jae Lee, Sivan G. Marcus, Laure Dumont, Bruce R. Conklin, Holger Willenbring, Luke P. Lee, and Kevin E. Healy. “Human Induced Pluripotent Stem Cell-Based Microphysiological Tissue Models of Myocardium and Liver for Drug Development.” Stem Cell Research & Therapy 4 Suppl 1 (2013): S14. doi:10.1186/scrt375.
  • Healy, K. E., McDevitt, T. C., Murphy, W. L. & Nerem, R. M. Engineering the emergence of stem cell therapeutics. Sci. Transl. Med. 5, 207ed17 (2013).
  • Schmidt, R. C. & Healy, K. E. Effect of avidin-like proteins and biotin modification on mesenchymal stem cell adhesion. Biomaterials 34, 3758–62 (2013).

2012

  • Pollock, Jacob F., Randolph S. Ashton, Nikhil A. Rode, David V. Schaffer, and Kevin E. Healy. “Molecular characterization of multivalent bioconjugates by size-exclusion chromatography with multiangle laser light scattering.” Bioconjugate chemistry 23, no. 9 (2012): 1794-1801.

2011

  • Jeon, Hojeong, Ray Schmidt, Jeremy E. Barton, David J. Hwang, Lara J. Gamble, David G. Castner, Costas P. Grigoropoulos, and Kevin E. Healy. “Chemical patterning of ultrathin polymer films by direct-write multiphoton lithography.” Journal of the American Chemical Society 133, no. 16 (2011): 6138-6141.
  • Irwin, E. F., Gupta, R., Dashti, D. C. & Healy, K. E. Engineered polymer-media interfaces for the long-term self-renewal of human embryonic stem cells. Biomaterials 32, 6912–9 (2011).
  • Little, Lauren E., Karen Y. Dane, Patrick S. Daugherty, Kevin E. Healy, and David V. Schaffer. “Exploiting bacterial peptide display technology to engineer biomaterials for neural stem cell culture.” Biomaterials 32, no. 6 (2011): 1484-1494.

2010

  • Saha, K. et al. Surface creasing instability of soft polyacrylamide cell culture substrates. Biophys. J. 99, L94–6 (2010).
  • Wall, S. T., Yeh, C.-C., Tu, R. Y. K., Mann, M. J. & Healy, K. E. Biomimetic matrices for myocardial stabilization and stem cell transplantation. J. Biomed. Mater. Res. A 95, 1055–66 (2010).
  • Ananthanarayanan, B., Little, L., Schaffer, D. V, Healy, K. E. & Tirrell, M. Neural stem cell adhesion and proliferation on phospholipid bilayers functionalized with RGD peptides. Biomaterials 31, 8706–15 (2010).
  • Keung, A. J., Healy, K. E., Kumar, S. & Schaffer, D. V. Biophysics and dynamics of natural and engineered stem cell microenvironments. Wiley Interdiscip. Rev. Syst. Biol. Med. 2, 49–64 (2010).
  • Su, J., Wall, S. T., Healy, K. E. & Wildsoet, C. F. Scleral reinforcement through host tissue integration with biomimetic enzymatically degradable semi-interpenetrating polymer network. Tissue Eng. Part A 16, 905–16 (2010).
  • Wise, Joel K., et al. “Temporal gene expression profiling during rat femoral marrow ablation-induced intramembranous bone regeneration.” PloS one 5.10 (2010): e12987.

US Patents

  • Healy, K. Wall, S. Saha, K. Schaffer D. Polypeptide-polymer conjugates and methods of use thereof. (2019).
  • Healy, K. Wall, S. Saha, K. Schaffer D. Polypeptide-polymer conjugates and methods of use thereof. (2018).
  • Jha, A. Healy, K. Growth factor sequestering and presenting hydrogels. (2017).
  • Yeghiazarians, Y. Ye, J. Boyle, A. Healy, K. Jha, A. Cardiosphere derived cell population and methods of use. (2016).
  • Healy, K. Wall, S. Saha, K. Schaffer D. Polypeptide-polymer conjugates and methods of use thereof. (2016).
  • Healy, K. Wall, S. Ratcliffe, M. Guccione, J. Methods and compositions for stabilizing the myocardium. (2016)
  • Schaffer, D. Healy, K. Little, L. Daugherty, P. Synthetic cell platforms and methods of use thereof. (2015).
  • Wildsoet, C. Su, J. Healy, K. Implantable delivery vehicle for ocular delivery of muscarinic antagonists. (2014).
  • Fadeev, A. Gehman, J. Martin, A. Melkoumian, Z. Shogbon, C. Weber, D. Zhou, Y. Swellable (meth)acrylate surfaces for culturing cells in chemically defined media. (2012).
  • Healy, K. Wall, S. Ratcliffe, M. Guccione, J. Methods and compositions for stabilizing the myocardium. (2012).
  • Healy, K. Stile, R. Tunable, semi-interpenetrating polymer networks (sIPNS) for medicine and biotechnology. (2011).
  • Healy, K. Walsh, J. Dorfman, G. Thermo-mechanically expandable stent. (2004).
  • Healy, K. Walsh, J. Dorfman, G. Method for deploying a thermo-mechanically expandable stent. (2003).
  • Healy, K. Bearinger, J. Interfacial coatings. (1999).
  • Healy, K. Whang, K. Thomas, C. Method of fabricating emulsion freeze-dried scaffold bodies and resulting products. (1998).
  • Healy, K. Dorfman, G. Biodegradable stent. (1997).

 

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